ABSTRACT
Objective: To evaluate the elicitation and the duration of anti-SARS-Cov-2 neutralizing antibodies (nAbs) after BNT162b2 vaccination in subjects with Multiple Sclerosis (swMS) naïve or under therapy compared to Healthy Subjects (HS). Background: Questions have raised about anti-SARS-CoV2 vaccine efficacy in subjects under immunosuppressive/immunomodulatory therapies such as swMS. These therapies are often associated with qualitative and quantitative changes of the immune system, and thus may have implications on the efficacy of anti-SARS-CoV-2 vaccine due to a different elicitation of the immune response. The neutralizing capacity of vaccine-induced antibodies (Abs), as well as the duration of these nAbs is a fundamental issue to be addressed for the comprehension of how swMS respond to anti-SARS-CoV-2 vaccine. Design/Methods: Sera were collected from 71 swMS and 20 HS, before, 1 and 6 months after vaccination with BNT162b2 vaccine. Anti-SARS-CoV-2 nAbs were measured with an ELISA test that detects IgG directed toward the Receptor Binding Domain (RBD) localized on the Spike (S) protein of SARS-CoV-2, and by means of an in vitro antiviral test using SARS-CoV-2 pseudovirions engineered with the S protein. Results: At multivariable analysis, swMS showed a lower anti-RBD IgG production one month after vaccination with respect to HS. This was mainly due to a lower anti-RBD IgG production in swMS under anti-CD20, Fingolimod or Cladribine treatment. Conclusions: Anti-SARS-CoV2 vaccination elicits a comparable humoral immune response in swMS and HS, with the exception of swMS undergoing some immunodepleting therapies. The comprehension of the better timing of vaccination in these patients will be useful for the induction of a proper Abs response.
ABSTRACT
Developers collaborating with collective efforts in large-scale distributed software typically have different personalities that might play a central role in software development and in team climate. In this paper, we have investigated if personality traits are related to the perceived team climate of software developers (Computer Science master students) in a smart-working development context. In particular, we conducted a preliminary study with 53 master students of a Computer Science course conducting a project work during the Covid-19 pandemic. Participants were grouped into 19 distributed teams. We analyzed the correlation between personality traits and team climate factors and created a predictive model for Task Orientation using these correlations. Results suggest that the Extroversion personality trait (characteristic of social and easy-going people) is statistically significant. We also observed a (weak) positive correlation with considered team climate factors. © 2021, Springer Nature Switzerland AG.
ABSTRACT
The widespread of viral airborne diseases is becoming a critical problem for human health and safety, not only for the common cold and flu, but also considering more serious infection as the current pandemic COVID-19. Even if the current heating, ventilating and air conditioning (HVAC) systems limit the disease transmission by air, the air filters are susceptible to microbial colonization. In addition, viruses spread via droplets (aerosol) produced by direct or indirect contact with infected people. In this context, the necessity of an efficient HVAC system, able to capture and inactivate viruses- and bacteria-rich aerosols, thus preserving a safe indoor air environment and protecting people, is of enormous importance. The aim of this work is the assessment of the antiviral properties of a silver nanoclusters/silica composite coating deposited via co-sputtering technique on glass, on metallic fibre-based air filters as well as on cotton textiles. The selected human respiratory viruses are: respiratory syncytial virus (RSV), the human rhinovirus (HRV) and the influenza virus type A (FluVA). The coated air filters show that the nanostructured coating develops a strong virucidal activity against RSV and FluVA, but not against the HRV.
ABSTRACT
In Latin America, 15% of women are paid domestic workers. Being a job without social security or labor rights, almost 80% of this work is done informally. In this sense, the health of these domestic workers should be considered at least under three aspects: precarization of work, social inequality, and gender inequality. Before the need for regulatory frameworks aimed at reducing health inequalities among informal workers, Argentina and Uruguay promoted the enactment of labor laws regarding paid domestic work. This study describes the experiences of both countries, considering the scope and impact of this formalization process on health. The results indicate that formalizing paid domestic work had but a limited impact, with difficulties in applying the traditional model of paid work protection. This legitimation of labor rights may also pose more challenges and tensions for public health and occupational health, which are worsened in the context of the covid-19 pandemic.
ABSTRACT
In Latin America, 15% of women are paid domestic workers. Being a job without social security or labor rights, almost 80% of this work is done informally. In this sense, the health of these domestic workers should be considered at least under three aspects: precarization of work, social inequality, and gender inequality. Before the need for regulatory frameworks aimed at reducing health inequalities among informal workers, Argentina and Uruguay promoted the enactment of labor laws regarding paid domestic work. This study describes the experiences of both countries, considering the scope and impact of this formalization process on health. The results indicate that formalizing paid domestic work had but a limited impact, with difficulties in applying the traditional model of paid work protection. This legitimation of labor rights may also pose more challenges and tensions for public health and occupational health, which are worsened in the context of the covid-19 pandemic.